Abstract: During cardiovascular development, peristaltic contraction of the embryonic heart tube produces time-varying hemodynamic forces and pressure gradients across the atrioventricular canal. However, the relative importance of myocardial contraction and hemodynamic force to modulate cardiovascular morphogenesis in the non-Newtonian flow regime remains poorly understood. By developing the 4-D light-sheet fluorescent microscope and post-imaging machine-learning algorithms, […]